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SELECT, synthetic intelligence, gene enhancing, extra

SELECT, synthetic intelligence, gene enhancing, extra


November 28, 2023

2 min learn


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Healio | Cardiology At present compiled an inventory of the highest information from the 2023 American Coronary heart Affiliation Scientific Periods.

See under for the information readers had been most considering, together with outcomes of the SELECT, ORFAN and ORBITA-2 trials and extra.

Learn all of Healio’s AHA 2023 protection right here.

Semaglutide cuts cardiovascular threat by 20% in individuals with coronary heart illness, weight problems: SELECT

Within the SELECT trial, remedy with weekly injectable semaglutide 2.4 mg (Wegovy, Novo Nordisk) was superior to placebo for decreasing cardiovascular threat in adults with preexisting coronary heart illness and obese or weight problems however with out diabetes.

Perspective from Erin D. Michos, MD, MHS, Eugene Yang, MD, and Sean Heffron, MD. Learn extra

AI-enabled know-how independently predicts cardiac occasions based mostly on coronary irritation

A synthetic intelligence-based know-how (CaRi-Coronary heart, Caristo Diagnostics) that evaluates coronary irritation predicted threat for cardiac occasions in sufferers present process coronary CTA, in line with outcomes of the ORFAN research.

Perspective from Alan C. Kwan, MD. Learn extra

Early research suggests gene enhancing can decrease LDL ldl cholesterol through PCSK9 inhibition

A novel single-dose CRISPR base-editing infusion (VERVE-101, Verve Therapeutics) for sufferers with heterozygous familial hypercholesterolemia and superior CAD decreased serum PCSK9 and lowered LDL by as much as 55% in a single affected person.

Perspective from Karol Watson, MD, PhD. Learn extra

PCI improves angina signs vs. sham process in sufferers with secure CAD: ORBITA-2

In sufferers with secure angina and proof of ischemia, PCI improved angina signs at 12 weeks in contrast with a sham process, in line with outcomes from the ORBITA-2 trial.

Perspective from Samin Okay. Sharma, MD. Learn extra

Novel PCSK9 inhibitor recaticimab linked to sturdy LDL discount

Recaticimab (Jiangsu Hengrui Prescribed drugs), a novel anti-PCSK9 drug, conferred important LDL reductions at 48 weeks in a cohort of sufferers with combined hyperlipidemias already on statin remedy within the REMAIN-2 trial. Learn extra

Injectable antihypertensive drug lowers blood strain for as much as 6 months

Zilebesiran (Alnylam), an investigational subcutaneous RNA interference therapeutic, lowered systolic blood strain at 3 months and sustained the discount to six months, in line with outcomes of the section 2 KARDIA-1 trial.

Perspective from Sandra J. Taler, MD. Learn extra

Lepodisiran considerably lowers Lp(a) in early trial

In a section 1 research, lepodisiran was well-tolerated and produced dose-dependent reductions in lipoprotein(a) concentrations in adults with out CVD who had elevated lipoprotein(a) ranges.

Perspective from Karol E. Watson, MD, PhD. Learn extra

Issue XI inhibitor for AF drastically reduces bleeding vs. rivaroxaban in section 2 trial

Within the section 2b AZALEA-TIMI 71 trial, abelacimab (Anthos Therapeutics), a novel issue XI inhibitor, drastically decreased bleeding in contrast with rivaroxaban in sufferers with atrial fibrillation requiring stroke prevention.

Perspective from Christine M. Albert, MD, MPH. Learn extra

Smartphone-based speech evaluation app might predict worsening coronary heart failure

A novel smartphone-based speech evaluation know-how (HearO, Cordio Medical) predicted worsening coronary heart failure that might result in hospitalization.

Perspective from Clyde W. Yancy, MD, MSc. Learn extra

Irritation predicts occasions greater than ldl cholesterol in high-risk statin-intolerant sufferers

Within the CLEAR Outcomes cohort of sufferers with statin intolerance, irritation predicted threat for CV occasions and loss of life extra strongly than ldl cholesterol.

Perspective from Howard Weintraub, MD. Learn extra



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