Running a drug screening program is like staging an enormous cocktail party—and listening in on the proceedings. At cocktail parties, there’s so much small talk, but only a few meaningful conversations. Similarly, in drug screening programs, feeble drug-target interactions greatly outnumber the instances of high-affinity binding.
Imagine if you had to listen to every bit of a cocktail party’s banter. Surely, that would be tedious. Now, consider how much worse it would be to evaluate every drug-target interaction in a typical drug screen. Why, that would exhaust even the most…
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